These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
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NM_024852.4 → NP_079128.2 protein argonaute-3 isoform a
See identical proteins and their annotated locations for NP_079128.2
Status: REVIEWED
Description Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). Source sequence(s) AA251146, AK303929, AL138787, AL139286, BF979526, BX104163 Consensus CDS CCDS399.1 UniProtKB/Swiss-Prot B1ALI0, Q5TA55, Q9H1U6, Q9H9G7 UniProtKB/TrEMBL A8KA05 Related ENSP00000362287.3, ENST00000373191.9 Conserved Domains (4) summary cd02846Location:228 → 348 PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. … cd04657Location:393 → 818 Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the … pfam08699Location:177 → 227 ArgoL1; Argonaute linker 1 domain pfam16486Location:73 → 167 ArgoN; N-terminal domain of argonaute
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NM_177422.3 → NP_803171.1 protein argonaute-3 isoform b
See identical proteins and their annotated locations for NP_803171.1
Status: REVIEWED
Description Transcript Variant: This variant (2) has multiple differences in the coding region, which causes translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus than isoform a. Source sequence(s) AA251146, AL138787, BC025769, BF979526, BX104163 Consensus CDS CCDS400.1 UniProtKB/TrEMBL B4E1P5 Related ENSP00000246314.6, ENST00000246314.10 Conserved Domains (2) summary cd02846Location:1 → 114 PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. … cd04657Location:159 → 584 Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the …